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Isolation and Characterization of Bone Marrow Microenvironment in Myeloid Neoplasms

November 10th, 2023
1,2, 1,3, 1,3, 1,2, 1,3,4, 1,5, 1,3
1Wilmot Cancer Institute, University of Rochester Medical Center, 2Department of Biomedical Engineering, University of Rochester, 3Department of Biomedical Genetics, University of Rochester Medical Center, 4Genomics Research Center, University of Rochester Medical Center, 5Division of Endocrinology and Metabolism, Department of Medicine, University of Rochester Medical Center

Summary
Automatic Translation

Här presenteras ett detaljerat protokoll för att isolera och karakterisera benmärgsmikromiljöpopulationer från murina modeller av myelodysplastiska syndrom och akut myeloisk leukemi. Denna teknik identifierar förändringar i den icke-hematopoetiska benmärgsnischen, inklusive endotel- och mesenkymala stromaceller, med sjukdomsprogression.

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